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Biorreator/Fermentador Piloto SIP modelo F2

F2 models are the perfect solution for all those seeking for a sterilisable in place (SIP) bioreactor/ fermentor, incorporating the latest technology and offering both, a user friendly handling. 
A modular system designed and constructed under the highest quality standards, equipped for a simple operation that will be e easily integrated into your facilities.



Models:



- Available in two models (F2-15
and F2-30) with working volumes
of 15 and 30 liters, respectively,
and possibility to work with volumes between 6 and 30 liters.



- Available in self-sterilisation version with
integrated steam supply.

- cGMP
bioreactors and manufacturing under ASME-BPE standards available on demand. It includes CFR 21.11     version of ROSA+ SW.



Gas outlet 



-  Hygienic design. Outlet contention filter available
as an option.



-  Tubular condenser.



-  Single or double mechanical seal (sterilisable by steam injection).



-  Heating unit for outlet filter available
on demand.

Fermentor 

-   Vessel and product-contact surfaces made of stainless steel A316L and borosilicate glass.





-  15+ ports for instrumentation, addition, gas inlet and outlet.

Service Valves 

-  Harvest valve and sampling valve, sterilisable in place by
steam
supply



FCU 



-    Monitoring and additions
integrated in Bionet FCU through an
industrial PLC
(Siemens) and a 12” HMI Panel        PC, with ROSA+ control software installed.



-    Several external analog connections available for expansion, accessories and connectivity.



-    Ethernet port with LAN and VPN communication.



Additions 





-    3-4 peristaltic wall pumps, one with variable speed for fed-batch or continuous fermentation.



 Agitator 



-    Noiseless, top-mounted agitator with brushless
servomotor. Broad speed range, adapted depending on the            nature of the culture.



-    Available with 3 Rushton
impellers (6-blades)
or marine turbines (cell culture).





-    Single or double mechanical seal (sterilisable by steam injection).



Control and Monitoring 





-    Controlled parameters: pH,
dissolved O2 , temperature and level (foam).
Other parameters (OD, weight, exhaust
gas...) can be easily
added on demand,
even after the equipment delivery
and commissioning.



 Air supply





-  Includes flowmeter and automatic flow control, mass flow controller available as an option. 0,22μm sterile filter       in air inlet line. Sterilisable line and aseptic design.

-   Automatic process pressure control available
as an option



Accessibility and ergonomics





-  Accessibility accessories available for on-top operations
(staircase to sight glass and lid lifting crane).



 Safety



-  Aseptic burst disc in fermentor and overpressure relief valve.

-  Main switch.


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